Two of the drones were shot down and the third struck the compound at al-Tanf base where the borders of Syria, Iraq and Jordan meet, the U.S. military said.
The military said the drone that struck the building wounded two members of the Syrian Free Army, who received medical treatment.
The Britain-based Syrian Observatory for Human Rights, an opposition war monitor, said the attack was likely carried out by Iran-backed fighters who are deployed in different parts of war-torn Syria.
“Attacks of this kind are unacceptable — they place our troops and our partners at risk and jeopardize the fight against ISIS,” U.S. military spokesman Joe Buccino said, using an acronym for the Islamic State group.
There are roughly 900 U.S. troops in Syria, including in the north and the farther south and east of the country.
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